Super Refined™ polyethylene glycol 400. Super Refined PEGs are solvents for use with the most sensitive active ingredients across dosage forms including injectable and oral.
Super Refining removes polar impurities (including primary and secondary oxidation products) from an excipient without altering its chemical composition, reducing excipient-API interaction and subsequent API degradation. The benefits of Super Refined PEGs over standard pharmaceutical PEGs include:
• Better API stability and finished formulation integrity
• Reduced potential for cellular irritation
• Improved taste profile when used in oral liquid dosage forms
• Reduced crosslinking in gelatin capsules
Please download the datasheet for more detailed information.
Product details
Pharmacopoeia compliance
- FDA-IID listed
- JP/JPE
- Ph. Eur.
- USP/NF
Chemical group
- Ethoxylate
- Polyethylene glycol
Administration route
- Auricular
- Nasal
- Ophthalmic
- Oral
- Parenteral
- Rectal and vaginal
- Topical
Market application
- Human pharmaceutical
- Veterinary health
Functions
- Solvent
Physical form
- Colourless viscous liquid
PRODUCT USE CASE STUDY
"Patients want faster action for pain relief"
Technical barriers:
- Tableted products only release the product based on the API solubility and the tablet disintegrants
- Liquid solutions in capsules increase the risk of API degradation
- Liquid solutions can struggle to dissolve the therapeutic API dose
- Significant development time in formulations.
Solutions:
- Super Refined™ P35 Castor Oil disperses the API for rapid absorption and action
- Super Refined™ PEG 400 acts as the main solvent to successfully dissolve the therapeutic dose
- Croda's in house oral liquid dose formulation knowledge used to get to the right answer, fast.
After formulating with the two named products, the customer was unable to make the following pack claims:
- Fast action
- Liquid capsule.
Did you know Super Refined™ PEG 400 reduces the risk of cross linking in soft gel capsules?