Well-established as a common component in a variety of vaccines, Adju-Phos is an aluminium-based adjuvant that induces strong Th2 immune responses.
Adju-Phos is our aluminium phosphate gel that has been specifically developed for use as an adjuvant in vaccines. Adju-Phos has a net negative charge at neutral pH and effectively adsorbs positively charged antigens. Adju-Phos differentiates itself from Alhydrogel both chemically and structurally, both being amorphous aggregates of nanometre-size hydrous crystallites.
Like Alhydrogel, Adju-Phos primarily stimulates a Th2-mediated humoral response and can be combined with other adjuvants (such as monophosphoryl lipid-A and analogues) to imprint a different immune fingerprint, in the case of monophosphoryl lipid-A, a stronger and more balanced Th1/Th2 response.
Aluminium adjuvants are used in human vaccines for tetanus, diphtheria, pertussis, poliomyelitis, as well as hepatitis A and B.
We are the only global provider to offer aluminium-based adjuvants to such a high standard. Let us help you fulfil your adjuvant needs.
Adju-Phos is a registered trademark of Croda International Plc.
Product details
Chemical group
- Aluminium hydroxyphosphate
Administration route
- Vaccine adjuvant
Market application
- Human vaccines
- Veterinary vaccines
Functions
- Vaccine adjuvant
Physical form
- A gel-like aqueous suspension. A supernatant forms when the product is left idle.
cGMP manufacturing
We offer sterile and aseptically filled aluminium-based adjuvants. Our site in Denmark is a certified cGMP manufacturing plant. It is approved by the Danish Medicines Agency for the manufacture of sterile and aseptically filled intermediates in accordance with EU GMP Part 1 (Basic Requirements for Medicinal Products) and Annexe 1 (Manufacture of Sterile Medicinal Products).