Methoxypolyethyleneglycoloxy(2000)-N,N-ditetradecylacetamide
ALC-0159 is a polyethylene glycol (PEG)-lipid conjugate also called a PEGylated lipid. ALC-0159 is a lipid excipient that can be used to form lipid nanoparticles (LNPs).
Polyethylene glycol (PEG)-lipids have been the polymer-lipid conjugate of choice for lipid formulations for decades. PEG-lipids are used increase systemic circulation times, mediate indirect targeting capabilities, promote LNP self-assembly, control size and aid in storage stability. Particles containing PEG-lipids are able to bypass the reticulo-endothelial system, giving them their nickname - “stealth agents”. ALC-0159 is not a traditional phospholipid as it contains two saturated 14-carbon chains joined at a nitrogen atom which is then linked to the poly(ethylene glycol).
Functions include:
- Increased half life when administered systemically
- Aids in storage ability
- Helps obtain small particle sizes