Why is it important to remove impurities in cell culture media ingredients?

Impurities in cell culture media ingredients can interfere with cell growth, viability, or their ability to produce protein yields or viral titres, introducing variability and unpredictability into your bioprocess. Super Refined™ Poloxamer 188 removes hydrophobic impurities and other potential contaminants, ensuring uninhibited cell culture performance.

Why is batch-to-batch consistency important in raw materials for cell culture?

Batch-to-batch consistency of the raw materials added to cell culture media is essential for consistent cell culture performance. Variability in raw material quality can lead to fluctuations in cell performance, affecting yields, product quality, and downstream processing efficiency. Super Refined™ Poloxamer 188 ensures consistent impurity profiles across every batch, reducing the risk of batch failure and enhancing overall process control.

How does Super Refined™ Poloxamer 188 ensure batch-to-batch consistency in cell culture performance?

All of the products in our <a href="/en-gb/drug-delivery-solutions/explore-by-product/super-refined">Super Refined™</a> range are held to the highest standard of purity and quality. We achieve batch-to-batch consistency through stringent quality control measures, including tightly controlled impurity profiles, analytical testing, and comprehensive Certificate of Analysis documentation. Each batch of Super Refined™ Poloxamer 188 meets the specifications of the USP, Ph. Eur., and JPE monographs, with its ChP status currently in progress. This consistency reduces the risk of variability in cell culture performance, ensuring reproducible results biomanufacturing processes.

What cell lines can benefit from Super Refined™ Poloxamer 188 in their cell culture media?

Super Refined™ Poloxamer 188 is particularly beneficial for mammalian cell lines like CHO (Chinese Hamster Ovary) and HEK (Human Embryonic Kidney) cells, which are widely used in the production of monoclonal antibodies, vaccines, and recombinant proteins. It supports cell membrane integrity, reduces shear stress during agitation in bioreactors, and enhances overall cell viability.

What are some of the added benefits of working with Super Refined™ Poloxamer 188?

In addition to unmatched purity and consistency, Super Refined™ Poloxamer 188 provides multi-compendial compliance (USP, Ph. Eur., and JPE; ChP in progress) to ensure global regulatory acceptance. Enhanced packaging further protects product integrity and extends product shelf life. By eliminating contaminants and batch variability, Super Refined™ Poloxamer 188 helps streamline downstream processing, saving time and costs in biomanufacturing.

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Super Refined™ Poloxamer 188

Q: How does Super Refined™ Poloxamer 188 ensure batch-to-batch consistency in cell culture performance?

All of the products in our <a href="/en-gb/drug-delivery-solutions/explore-by-product/super-refined">Super Refined&trade;</a> range are held to the highest standard of purity and quality. We achieve batch-to-batch consistency through stringent quality control measures, including tightly controlled impurity profiles, analytical testing, and comprehensive Certificate of Analysis documentation. Each batch of Super Refined&trade; Poloxamer 188 meets the specifications of the USP, Ph. Eur., and JPE monographs, with its ChP status currently in progress. This consistency reduces the risk of variability in cell culture performance, ensuring reproducible results biomanufacturing processes.

Q: What cell lines can benefit from Super Refined™ Poloxamer 188 in their cell culture media?

Super Refined&trade; Poloxamer 188 is particularly beneficial for mammalian cell lines like CHO (Chinese Hamster Ovary) and HEK (Human Embryonic Kidney) cells, which are widely used in the production of monoclonal antibodies, vaccines, and recombinant proteins. It supports cell membrane integrity, reduces shear stress during agitation in bioreactors, and enhances overall cell viability.

Super Refined™ Poloxamer 188 is added to mammalian cell culture media to protect cells from shear stress caused by agitation in a bioreactor. Super Refined™ Poloxamer 188 has been optimised specifically for mammalian cell culture with tightly controlled impurity profiles and molecular weight, ensuring optimal cell culture performance and batch-to-batch consistency. As a product belonging to our Super Refined™ range, Super Refined™ Poloxamer 188 meets excellent purity standards, undergoes rigorous quality testing, is offered in enhanced packaging, and is also suitable for use as a parenteral excipient in biologic formulations.

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Product details

Pharmacopoeia compliance

JP/JPE
Ph. Eur.
USP/NF

Chemical group

Non-ionic triblock polymer
Polyethylene oxide-polypropylene oxide block copolymer (PEO-PPO-PEO)

Administration route

Parenteral

Market application

Biomanufacturing
Bioprocessing
Cell culture
Human pharmaceutical
Upstream bioprocessing

Functions

Shear stress-protectant

Physical form

Free-flowing granular white powder

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