Super Refined Polysorbates solubilise and stabilise the most sensitive active ingredients across dosage forms including injectable and oral.
Super Refining removes impurities (including primary and secondary oxidation products) from an excipient without altering its chemical composition, helping to reduce API interaction and degradation. The benefits of Super Refined Polysorbates over standard pharmaceutical polysorbates include:
Better API stability and finished formulation integrity
Reduced potential for cellular irritation
Improved taste profile when used in oral liquid dosage forms.
Product details
Pharmacopoeia compliance
- ChP
- FDA-IID listed
- Ph. Eur.
- USP/NF
Chemical group
- Ester
- Polysorbate
- Sorbitan ester
Administration route
- Auricular
- Nasal
- Ophthalmic
- Oral
- Parenteral
- Rectal and vaginal
- Topical
Market application
- Blood plasma fractionation
- Human pharmaceutical
- Human vaccines
- Veterinary health
Functions
- Bioprocessing
- Emulsifier
- Plasticiser
- Solubiliser
- Wetting agent
Physical form
- Clear, essentially colourless liquid
HLB
- 15.00
Webinars
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25 mins
Polysorbates in Biopharmaceutical Formulations
13 Sep 2021 | English
Dr. Rumbelow will discuss the key role polysorbates play in stabilizing biopharmaceutical formulations and their excellent performance in preventing protein aggregation across a huge range of biopharmaceutical activities.
Croda, established in 1925 is known for some of our best selling and most studied excipients, polysorbates. Steve will cover the complex nature of polysorbates and how differences in purity levels in the various grades of commercially available polysorbate can impact performance. In addition, how the various grades and indeed specific components of polysorbates, can impact formulation stability, including changes in formulation stability and issues around protein self-aggregation.
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