Are you attending AAPS PharmaSci 360?
AAPS PharmSci 360 is known as the “home for pharmaceutical scientists” where attendees network across the entire drug development and delivery continuum, end to end.
Croda Pharma and Avanti Research will be highlighting our Small Molecule Delivery solutions, ranging from Super Refined™ high purity excipients through to our expertise in lipid formulation.
We will also be presenting on our products supporting the biomanufacturing process, both upstream and downstream, including our NEW product launch, soon to be revealed!
Where you can find us:
- When: October 20-23, 2024
- Where: Salt Palace Convention Center, Salt Lake City, UT
- Booth location: 2525
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Poster sessions...
Dr. Veronica Blanco
Accelerating SEDDS formulation development with machine learning
Excipients are fundamental components in the drug development process. They are essential in the formulation of stable dosage forms, ensuring that medications maintain their efficacy and safety throughout their shelf life. This study aimed to evaluate the effect of excipient purity on the stability of two chemotherapy drugs under accelerated conditions, seeking to understand how varying levels of excipient purity can impact oncological drug formulations.
- Poster number: T1130-09-51
- Poster presentation: Tuesday, 11:30am, Forum 09 on Monitor 51
Excipient purity on the stability of chemotherapy drugs
Self-emulsifying drug delivery systems (SEDDS) and self-microemulsifying drug delivery systems (SMEDDS) have emerged as promising approaches in pharmaceutical formulations to enhance the solubility and bioavailability of poorly water-soluble drugs. However, optimization of SEDDS and SMEDDS formulations is a complex and time-consuming process. Here, we aim to accelerate this process by using machine learning to predict the stability of binary and tertiary blends containing a wide range of excipients.
- Poster number: W0930-09-48
- Poster presentation: Wednesday, 9:30am, Forum 09 on Monitor 48
Visit our talk...
TUESDAY OCTOBER 22, 9:30AM, ROLE OF KEY RAW MATERIALS IN IMPROVING YIELD AND SAFETY IN BIOMANUFACTURING
The biomanufacturing process consists of several critical stages that impact the final yield and safety profile of biological products. Two pivotal factors in this process involve maintaining cell health during the upstream phase and viral inactivation during the downstream phase. Using high-purity, low molecular weight Poloxamer 188 in cell culture media enhances cell health.
Subsequently, during downstream processing to meet the FDA's viral inactivation requirement, a non-ionic, sustainable detergent can significantly reduce the viral burden.
Objectives:
- Improving cell health in biomanufacturing
- Improving safety profile by increasing viral clearance using a sustainable alternative to TritonX 100 detergent
- Critical quality attributes of raw materials in bioprocessing and the importance of batch-to-batch consistency.
