Super Refined™ excipients for topical drug delivery
Common issues affecting topical formulation include active pharmaceutical ingredient (API) instability, poor API solubilisation, and skin irritation that can lead to reduced patient compliance. Our Super Refined excipients address these formulation concerns and maximise the value of your topical drug product.
High purity excipients for topical drug delivery
Our proprietary Super Refining process yields highly purified excipients that can maximise drug product value and are indicated to stabilise, solubilise and optimise the active ingredients in the formulation.
Maximising API stability
To demonstrate enhanced API stability, we monitored the percentage of the API lidocaine that could be recovered over time when incorporated into Super Refined Crodamol™ OO (oleyl oleate) versus standard compendial oleyl oleate. It can be seen that lidocaine maintains its integrity and stability far better in Super Refined Crodamol OO, with significantly less API being recovered from standard compendial grade oleyl oleate.
Maximising oxidative stability
To demonstrate oxidative stability, the peroxide value of Super Refined Crodamol OO was compared to standard compendial grade oleyl oleate over a 40 day study in accelerated ageing temperatures. It was noted that the Super Refined excipient maintained a low peroxide value while the standard compendial grade exhibited an approximate 70-fold increase in peroxide value, indicating that it has undergone significant primary oxidation.
Your partner for topical formulations
The efficacy of our dermatological ingredients is demonstrated by clinical studies across a range of therapies including skin hydration and barrier repair applications, emollient therapy and wound healing.
Super Refined™ pharmaceutical excipients
Small Molecule Delivery
Explore some of our pharmaceutical excipients:
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Cithrol™ GMS 40 pharma
Emulsionante no iónico, estabilizante de emulsión W / O y O / W, dispersante y emoliente utilizado en preparaciones farmacéuticas orales y tópicas. Se utiliza para formar matrices de liberación sostenida...Agregar a favoritos Agregar producto a favoritos -
Crodasol™ HS HP
Crodasol HS HP es un tensioactivo no iónico de alta pureza que proporciona excelentes propiedades de solubilización. Conforme a las monografías PhEur, es una mezcla de monoésteres y diésteres de ácido...Agregar a favoritos Agregar producto a favoritos -
Liquid Medilan™ Ultra
Aceite de lanolina Super refinada ultra-pura clínicamente probada para reducir los signos y los síntomas de la piel extremadamente seca y agrietada. Ofrece propiedades estéticas superiores como emoliente...Agregar a favoritos Agregar producto a favoritos -
Medilan™ Super
Fabricada utilizando el proceso de Super Refining de Croda para crear un producto de calidad médica con una estética superior. Este producto es adecuado para las condiciones comprometidas de la piel como...Agregar a favoritos Agregar producto a favoritos -
Medilan™ Ultra
Grado ultra-puro de lanolina médica con reparación de capas y propiedades curativas de heridas. Sus propiedades estéticas excepcionales y su bajo arrastre lo hacen particularmente adecuado para aplicaciones...Agregar a favoritos Agregar producto a favoritos -
Span™ 20 HP
Nuestra gama Span de ésteres de sorbitán altamente purificados son ideales para uso en aplicaciones que requieren una especificación de pureza más estricta que las ofertas estándar de Span. En los grados...Agregar a favoritos Agregar producto a favoritos -
Span™ 80 HP
Nuestra gama Span de ésteres de sorbitán altamente purificados son ideales para uso en aplicaciones que requieren una especificación de pureza más estricta que las ofertas estándar de Span. En los grados...Agregar a favoritos Agregar producto a favoritos
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Eczema
Eczema is a group of inflammatory skin disorders characterised by itchiness, dryness, scaling, sensitivity, cracking, and inflammation. Our dermatological solutions are designed to address these symptoms in a range of convenient formulations.
Our star excipient: Medilan™ (Wool Fat PhEur; Modified Lanolin NF), approved by the British Skin Foundation
- Replenishes the skin’s essential lipids
- Repairs the natural skin barrier to reduce transepidermal water loss
- Excellent skin hydration properties
- Provides long lasting emollience.
Featured
Medilan™
Arlamol™ PS11E pharma
Baby skin
Baby skin has a delicate and fragile structure which easily becomes dry or irritated due to urine contact, laundry detergent residues and central heating and air conditioning. Formulating for baby skin requires mild, effective moisturising ingredients and a dosage form that is quick and easy to apply or use in the bath.Our star excipeint: Arlamol™ PS11E (Polyoxypropylene Stearyl Ether PhEur)
- Excellent polar solvent for a wide range of actives
- Non-occlusive emollient offering a velvety skin feel
- Enables compatibility of polar and non-polar oils, making it possible to couple two actives into one product
- Produces liquid crystal oleosomes when used with Brij S2, Brij S721 and Crodacol CS90. Oleosome systems enable longer lasting skin hydration, pH flexibility, and increased salt tolerance and stability.
Super Refined™ excipients
We have a large variety of products, ranging from various polysorbates, polyethylene glycols (PEG), esters, vegetable oils, and more.
