Polyethylene glycol (PEG)-lipids have been the polymer-lipid conjugate of choice for lipid formulations for decades. PEG-lipids are used increase systemic circulation times, mediate indirect targeting capabilities, promote LNP self-assembly, control size and aid in storage stability. Particles containing PEG-lipids are able to bypass the reticulo-endothelial system, giving them their nickname - “stealth agents”. ALC-0159 is not a traditional phospholipid as it contains two saturated 14-carbon chains joined at a nitrogen atom which is then linked to the poly(ethylene glycol). Increased half life when administered systemically, aids in storage ability, helps obtain small particle sizes.
Detalles del producto
Grupo quimico
- Glicérido
- PEG lipídico
- Polímero
Vía de administración
- Parenteral
Aplicación comercial
- Producto farmacéutico humano
- Salud veterinaria
- Vacunas para uso humano
- Vacunas veterinarias
Funciones
- Excipiente
Forma física
- Powder
Folletos y guías de productos
Category: Ficha general del producto
Title: Avanti's range of innovative lipids
GMP lipid catalog
Language: Inglés | Size: 221.74kb
Identifíquese