Super Refined™ Poloxamer 188 is added to mammalian cell culture media to protect cells from shear stress caused by agitation in a bioreactor. Super Refined™ Poloxamer 188 has been optimised specifically for mammalian cell culture with tightly controlled impurity profiles and molecular weight, ensuring optimal cell culture performance and batch-to-batch consistency. As a product belonging to our Super Refined™ range, Super Refined™ Poloxamer 188 meets excellent purity standards, undergoes rigorous quality testing, is offered in enhanced packaging, and is also suitable for use as a parenteral excipient in biologic formulations.
Detalles del producto
Pharmacopoeia compliance
- JP/JPE
- Ph. Eur.
- USP/NF
Grupo quimico
- Copolímero en bloque de óxido de polietileno-óxido de polipropileno (PEO-PPO-PEO)
- Copolímero tribloque no iónico
Vía de administración
- Parenteral
Aplicación comercial
- Biofabricación
- Bioprocesamiento
- Bioprocesamiento upstream
- Cultivo celular
- Producto farmacéutico humano
Funciones
- Shear stress-protectant
Forma física
- Free-flowing granular white powder
Frequently Asked Questions
Impurities in cell culture media ingredients can interfere with cell growth, viability, or their ability to produce protein yields or viral titres, introducing variability and unpredictability into your bioprocess. Super Refined™ Poloxamer 188 removes hydrophobic impurities and other potential contaminants, ensuring uninhibited cell culture performance.
Batch-to-batch consistency of the raw materials added to cell culture media is essential for consistent cell culture performance. Variability in raw material quality can lead to fluctuations in cell performance, affecting yields, product quality, and downstream processing efficiency. Super Refined™ Poloxamer 188 ensures consistent impurity profiles across every batch, reducing the risk of batch failure and enhancing overall process control.
All of the products in our Super Refined™ range are held to the highest standard of purity and quality. We achieve batch-to-batch consistency through stringent quality control measures, including tightly controlled impurity profiles, analytical testing, and comprehensive Certificate of Analysis documentation. Each batch of Super Refined™ Poloxamer 188 meets the specifications of the USP, Ph. Eur., and JPE monographs, with its ChP status currently in progress. This consistency reduces the risk of variability in cell culture performance, ensuring reproducible results biomanufacturing processes.
Super Refined™ Poloxamer 188 is particularly beneficial for mammalian cell lines like CHO (Chinese Hamster Ovary) and HEK (Human Embryonic Kidney) cells, which are widely used in the production of monoclonal antibodies, vaccines, and recombinant proteins. It supports cell membrane integrity, reduces shear stress during agitation in bioreactors, and enhances overall cell viability.
In addition to unmatched purity and consistency, Super Refined™ Poloxamer 188 provides multi-compendial compliance (USP, Ph. Eur., and JPE; ChP in progress) to ensure global regulatory acceptance. Enhanced packaging further protects product integrity and extends product shelf life. By eliminating contaminants and batch variability, Super Refined™ Poloxamer 188 helps streamline downstream processing, saving time and costs in biomanufacturing.