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Several excipients in combination were required to achieve high drug solubility for a long lasting effect, the drug was prone to oxidation in excipients and some key solubilising excipients have a strong unpleasant odour.
Super Refined™ solutions for transdermal drug delivery systems
Transdermal drug delivery systems (TDDS) deliver specific doses of medication through the skin into the systemic circulation for therapeutic effects. TDDS is a non-invasive, painless method of delivering drugs, by applying a drug formulation onto intact and healthy skin and has recently emerged as an alternative to conventional needle injections. Benefits include ease of administration, convenience, and persistence amongst patients.
Our Super Refined™ excipients ensure that your formulation is stable, effective, and consistent, and thanks to their high purity they also have a reduced skin irritation effect, compared to standard grade excipients.
Advantages of transdermal delivery systems
- Controlled release
- Improved drug bioavaiability
- Self-administration and reduced dosing frequency
- Minimises adverse effects and easy to terminate
- Suited for lipholic active pharmaceutical ingredient (API).
Disadvantages of transdermal delivery systems
- Possibility of local skin irritation
- Use of multiple patches can lead to medication error.
Consumer Health
Our main goal in Consumer Health is to help our customers market consumer relevant label claims that grow their product and brand authority. We combine our technical expertise with regulatory knowledge to help our customers market innovative products.
Transdermal excipient selection criteria
- Selection of patch design
- Solubility between API and excipient blend
- Physical and chemical compatibility between API and excipient blend
- Impact of excipient blend on skin permeation
- Impact of excipient blend on non-drug substance related impurities
- Impact of excipients on adherence for duration of wear period.
How our high purity excipients can help
- Excellent API solubility
- Excellent oxidation stability
- Excellent hydrolysis stability
- Low cellular irritation
- Better skin permeation enhancement
- Reduced odour impact.
Product benefits and claims
Our range of excipients are multicompendial and meet standards of international pharmacopoeias. Our products offer batch to batch consistency and our global manufacturing infrastructure, expert regulatory support and application know-how make us the partner of choice!
We help our customers formulate medicines with claims relevant to their customers, increasing the superiority of their product and brand.
We help our customers formulate medicines with claims relevant to their customers, increasing the superiority of their product and brand.
Product recommendations
9 itens disponíveis
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Super Refined™ PEG 400
Super Refined PEGs são solventes para uso com os mais sensíveis ingredientes ativos em diversas formas de dosagens, incluindo oral e injetável. O processo Super Refining remove impurezas polares (incluindo...Adicionar a favoritos Adicionar produto aos favoritos -
Super Refined™ IPM
Miristato de Isopropilo de grau altamente purificado para uso em ingredientes farmacêuticos ativos sensíveis ou em aplicações onde Crodamol IPM não é recomendado. O processo exclusivo de Super Refining...Adicionar a favoritos Adicionar produto aos favoritos -
Super Refined™ Polysorbate 80
Super Refined Polysorbates solubilizam e estabilizam os mais sensíveis ingredientes ativos em diversas formas de dosagens, incluindo oral e injetável. O processo Super Refining remove impurezas polares...Adicionar a favoritos Adicionar produto aos favoritos -
Crodamol™ DA pharma
Éster com viscosidade muito baixa, solúvel em álcool e sistemas alcoólicos aquosos. Excelente solvência e espalhabilidade. Necessário HLB de valor 9. Níveis de uso tópico recomendados de 0,5-5%.Adicionar a favoritos Adicionar produto aos favoritos -
Super Refined™ Oleic Acid
Super Refined Oleic Acid é um ácido oleico altamente purificado apropriado para uso em aplicações tópicas, orais e nasais. Age como um solubilizante, agente emulsificante e potencializador de penetração...Adicionar a favoritos Adicionar produto aos favoritos -
Super Refined™ Propylene Glycol
Super Refined Propylene Glycol é um propilenoglicol altamente purificado que encontra aplicação como solvente, agente solubilizante, cosolvente miscível em água, plastificante, umectante, desinfectante...Adicionar a favoritos Adicionar produto aos favoritos -
Super Refined™ Oleyl Alcohol
Super Refined Oleyl Alcohol é um solubilizante altamente purificado à base de lipídios e um potencializador de penetração cutânea que age como um agente umectante e dispersante ativo em cremes tópicos...Adicionar a favoritos Adicionar produto aos favoritos -
Super Refined™ Oleyl Oleate
Versão de alta pureza do Oleato de Oleíla. Um emoliente vegetal leve e não gorduroso.Adicionar a favoritos Adicionar produto aos favoritos -
Super Refined™ IPP
Palmitato de isopropilo de grau farmacêutico altamente purificado. Espalhante e emoliente seco não oclusivo. Valor HLB exigido de 10. Nível de utilização tópico recomendado de 0,5-5%.Adicionar a favoritos Adicionar produto aos favoritos
Super Refined™ PEG 400, Super Refined Castor Oil and Crodamol™ DA Pharma offer the API solubility required when combined.
Crodamol DA Pharma is low in odour compared to competitor diisopropyl adipate
Super Refined Polysorbate 80 helps compatibilise the formulation excipients
Our Super Refined excipients and Crodamol DA Pharma have superior stability, protecting the formulation from drug degradation.
Crodamol DA Pharma is low in odour compared to competitor diisopropyl adipate
Super Refined Polysorbate 80 helps compatibilise the formulation excipients
Our Super Refined excipients and Crodamol DA Pharma have superior stability, protecting the formulation from drug degradation.
Pack claims unlocked:
- Odourless
- Fast acting pain relief
- Less frequent application.