Polyethylene glycol (PEG)-lipids have been the polymer-lipid conjugate of choice for lipid formulations for decades. PEG-lipids are used increase systemic circulation times, mediate indirect targeting capabilities, promote LNP self-assembly, control size and aid in storage stability. Particles containing PEG-lipids are able to bypass the reticulo-endothelial system, giving them their nickname - “stealth agents”. ALC-0159 is not a traditional phospholipid as it contains two saturated 14-carbon chains joined at a nitrogen atom which is then linked to the poly(ethylene glycol). Increased half life when administered systemically, aids in storage ability, helps obtain small particle sizes.
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