The chemical name for DSPE PEG 2000 Carboxylic Acid is 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000] (sodium salt) or DSPE-PEG-COOH. Based on the polydispersity of PEG, its molecular weight is 2780.38, and its exact mass is 2778.7. This specialized lipid molecule has been used in various applications in the field of biotechnology, pharmaceuticals, and drug delivery. It is a derivative of phospholipids and is part of the broader family of liposomal formulations.The DSPE's hydrophobic characteristics facilitate the encapsulation and gathering of other hydrophobic drugs. In the presence of an activator like EDC or HATU, the -COOH group can readily react with primary amines, resulting in the formation of a stable amide bond. DSPE-PEG 2000 carboxylic acid has been utilized to attach ITGA2 antibodies to liposome surfaces, create atosiban-conjugated liposomes, and produce dual complementary liposomes.
Polyethylene glycol (PEG)-lipids have been the polymer-lipid conjugate of choice for lipid formulations for decades. PEG-lipids are used increase systemic circulation times, mediate indirect targeting capabilities, promote LNP self-assembly, control size and aid in storage stability. Particles containing PEG-lipids are able to bypass the reticulo-endothelial system, giving them their nickname - “stealth agents”. The DSPE lipid anchor has 2 saturated 18-carbon chains which adds structure to the bilayer as well. The carboxylic acid is available at the terminus of the PEG group to aid in conjugation chemistry for targeting ligands or antibodies.
Functions include:
- Increased half life when administered systemically
- Aids in storage ability
- Helps obtain small particle sizes.
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